Strain Fidelity of Chronic Wasting Disease upon Murine Adaptation
نویسندگان
چکیده
منابع مشابه
Strain fidelity of chronic wasting disease upon murine adaptation.
Chronic wasting disease (CWD), a prion disease of deer and elk, is highly prevalent in some regions of North America. The establishment of mouse-adapted CWD prions has proven difficult due to the strong species barrier between mice and deer. Here we report the efficient transmission of CWD to transgenic mice overexpressing murine PrP. All mice developed disease 500 +/- 62 days after intracerebr...
متن کاملChronic Wasting Disease Prion Strain Emergence and Host Range Expansion
Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95+, into mice resulted in infection. Thus, emergent CWD prion strains may have higher zoonotic potential than common strains.
متن کاملChronic Wasting Disease
Chronic wasting disease (CWD) is a neurodegenerative disease, caused by a prion that affects cervids including deer, elk and moose. Until recently, CWD was an obscure illness that seemed to be found only in a small geographic area in northeastern Colorado and southeastern Wyoming. However, this disease has now been detected in wild and farmed cervids in many other U.S. states and Canada. Korea ...
متن کاملChronic Wasting Disease
Last Updated: October 8, 2008 Importance Chronic wasting disease (CWD) is a neurodegenerative disease, caused by a prion that affects cervids including deer, elk and moose. Until recently, CWD was an obscure illness that seemed to be found only in a small geographic area in northeastern Colorado and southeastern Wyoming. However, this disease has now been detected in wild and farmed cervids in ...
متن کاملChronic Wasting Disease
Chronic wasting disease (CWD) is a unique transmissible spongiform encephalopathy (TSE) of mule deer (Odocoileus hemionus), white-tailed deer (O. virginianus), and Rocky Mountain elk (Cervus elaphus nelsoni). The natural history of CWD is incompletely understood, but it differs from scrapie and bovine spongiform encephalopathy (BSE) by virtue of its occurrence in nondomestic and free-ranging sp...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2006
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01120-06